Expression of Π Class Glutathione-s-transferases in Mice Liver under the Influence of Paracetamol Treatment and the Recovery of Π Gsts to Μ Class Glutathione-s-transferases with Hybanthus Enneaspermus (l.) F. Muell. Treatment
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چکیده
The present study was designed to investigate the expression of GSTs under the influence of paracetamol and Hybanthus enneaspermus. Study with different substrates of glutathione-s-transferases were done to know the expression of GSTs. Along with this purification and isolation of GSTs were performed to know the expression of subunits of liver GSTs.Three subunits were found. Newly π GSTs were expressed upon treatment with paracetamol.In control liver μ GSTs are generally expressed. Hence the selected plant Hybanthus enneaspermus showed the recovery of π into μ GSTs in the case of liver.
منابع مشابه
Class-Pi of Glutathione S-Transferases
Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
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تاریخ انتشار 2013